mTOR

PI3K, AKT, mTOR, S6K

MTOR; mTOR

mechanistic target of rapamycin kinase

This protein is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression.

https://www.ncbi.nlm.nih.gov/gene/2475

https://www.cellsignal.cn/pathways/mtor-signaling-pathway

rapamycin; 雷帕霉素

https://en.wikipedia.org/wiki/Sirolimus

S6K

https://www.ncbi.nlm.nih.gov/gene/6198

S6K phosphorylates ribosomal protein S6 (RPS6)
https://www.nature.com/articles/onc2012606

SIR2

SIRT1; sirtuin 1; silent information regulator 1

https://www.ncbi.nlm.nih.gov/gene/23411

SIRT1 is a deacetylase that is transcribed in response to caloric restriction. It inhibits the transcription of rRNA and subsequently reduces ribosome biogenesis.