H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-O，198284-64-9，间隙连接抑制剂

序列(三字母)：H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH

序列(单字母)：SRPTEKTIFII

别名:Gap Junction α-1 Protein (200-210) (human, mouse, rat), Connexin 43 (200-210) (human, mouse, rat), Cx43 (200-210) (human, mouse, rat)

分子式:C60H101N15O17

分子量:1304.53

CAS#:198284-64-9

合成方法：Synthetic

存储条件：-20 °C，避光，干燥

应用：Regenerative Medicine

产品描述：GAP27是一种合成的 connexin43 模拟肽，是一种间隙连接抑制剂。GAP27可以抑制内皮细胞的间隙连接信号。GAP27也可以减弱ACh-诱导的动脉松弛和减少体内完整内皮细胞脉管钾离子调节平滑肌的复极化。

外观White lyophilised solid

溶解性Soluble to 1 mg/ml in water

参考文献:

1. Connexin-mimetic peptide Gap 27 decreases osteoclastic activity. Ilvesaro J, et al. BMC Musculoskelet Disord. 2001;2:10.

2. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Edwards G, et al. Br J Pharmacol. 1999 Dec;128(8):1788-94.

3. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. Chaytor AT,e t al. J Physiol. 1998 Apr 15;508 ( Pt 2):561-73.